Multiple Forms of DNA Polymerase in Mouse Myeloma
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چکیده
منابع مشابه
Multiple forms of DNA polymerase in mouse myeloma.
FIVE DISTINCT FORMS OF DNA POLYMERASE (DEOXYNUCLEOSIDETRIPHOSPHATE: DNA deoxynucleotidyltransferase, EC 2.7.7.7) were separated from extracts of mouse myeloma MOPC-104E using a fractionation procedure based upon sequential ion-exchange column chromatography. The enzymes were characterized according to sedimentation behavior, subcellular localization, chromatographic behavior on hydroxyapatite c...
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disease can be distinguished from one another and from control human polymerases by their elution behavior upon diethylaminoethyl cellulose chromatography and Sephadex gel filtration, by the magnesium ion concentration for optimal activity, by the stimulatory or inhibitory effects upon enzymatic activity of monovalent cations, and by sensitivity of enzymatic activity to heparin inhibition. Thes...
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Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma. Methods: Methylation status of S...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1974
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.71.2.578